HIPERTENSÃO PULMONAR NA INFECÇÃO VIH/SIDA: UMA DOENÇA RARA | PULMONARY HYPERTENSION IN AIDS/HIV INFECTION: A RARE DISEASE

Catarina Cardoso, Diva Trigo, Patricia Pacheco

Resumo


RESUMO
A Hipertensão pulmonar (HTP) é uma patologia rara mas que condiciona elevada morbilidade e mortalidade. É conhecida
a sua associação com o Vírus da Imunodeficiência Humana (VIH), mas muitos dos mecanismos implicados na sua patogénese
bem como o impacto da terapêutica antiretroviral (TARV) no tratamento e prognóstico desta doença ainda se encontram
por definir.
Apresenta-se um caso clínico de uma doente de 62 anos com infecção VIH internada por um quadro interpretado inicial-
mente como infecção respiratória. A má evolução e os exames adicionais permitiram o diagnóstico de Hipertensão pulmonar
grave que viria a determinar o falecimento da doente em poucos dias.
Atendendo à elevada prevalência de doentes com infecção VIH, é expectável o aumento do número de casos de Hipertensão
pulmonar, pelo que se chama a atenção para a necessidade de um diagnóstico precoce antes da evolução da mesma.


Palavras-chave: Hipertensão pulmonar, Vírus Imunodeficiência Humana, Terapêutica antiretroviral, Diagnóstico


ABSTRACT
Pulmonary hypertension is a rare disease with significant morbidity and mortality. Its association with HIV infection is well known
but other viral mechanisms involved are yet to be discovered as well as the impact of antiretroviral therapy (HAART) on the treatment and
prognosis.
We report a case of a 62 year-old HIV-infected female that was admitted with symptoms suggestive of a low respiratory tract infection.
Diagnostic test and the patient’s negative evolution allowed diagnosis of severe pulmonary hypertension which determined her death a few
days later.
Considering the rising prevalence of HIV infected patients, it is expected an increase on the number of Pulmonary Hypertension cases,
consequently, we raise awareness to the importance of an early diagnosis before its evolution.


Keywords: Pulmonary hypertension, Human Immunodeficiency Virus, Antiretroviral therapy, Diagnosis


Texto Completo:

PDF

Referências


Degano B, Guillaume M, Savale L, Montani D, Jais X, Yaici A et al HIV-associated pulmonary arterial hypertension: survival and prognostic

factors in the modern therapeutic era AIDS 2010;24:67-75

Galiè N, Hoeper MM, Humbert M, Torbicki A, Vachiery JL, Barbera JA et al Guidelines for the diagnosis and treatment of pulmonary hypertension

European Heart Journal 2009;30(20):2493-537

Correale M, Palmiotti GA, LoStorto MM, Montrone D, Barbaro MF, Di Biase M et al HIV-associated pulmonary arterial hypertension: from

bedside to the future Eur J Clin Invest 2015;4-6

Cicalini S, Chinello P, Grilli E, Petrosillo N Treatment and outcome of pulmonary arterial hypertension in HIV-infected patients: a review of

the literature Curr HIV Res 2009;7(6):589-96

Degano B, Guillaume M, Savale L, Montani D, Jais X, Yaici A et al HIV-associated pulmonary arterial hypertension: survival and prognostic

factors in the modern therapeutic era AIDS 2010;24:67-75

Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1 infected adults and

adolescents. Department of Health and Human Services [updated 2015 April 8] Available from http://aidsinfo.nih.gov/

Araújo I, Enjuanes-Grau C, Lopez-Guarch CJ, Narankiewicz D, Ruiz-Cano MJ, Velazquez-Martin T et al Pulmonary arterial hypertension

related to human immunodeficiency virus infection: A case series World Journ Cardio 2014;6:495-501

Pulido T, Adzerikho I, Channick RN, Delcroix M, Galiè N, Ghofrani HA et al Macitetan and morbidity and mortality in pulmonary arterial

hypertension N Engl J Med 2013; 369:809-19

Galia N, The AMBITION study: design and results. Presented at: 2014 European Respiratory Society Annual Meeting. Eur Respir J 2014; 44:

abstract no 2916

Pham P, Flexner C Emerging antiretroviral drug interactions J Antimicrob Chemother 2011;66 (2):235-239


Apontamentos

  • Não há apontamentos.